Chelation therapy is the administration of chelating agents to remove heavy metals from the body. Chelation therapy has a long history of use in clinical toxicology. In medicine, chelation has been scientifically proven to rid the body of excess or toxic metals.
Lee Silsby compounds a large number of chelators according to the practitioners specifications.
- Transdermal DMSA
- Other forms of DMSA
- EDTA (calcium) Suppositories
- EDTA (calcium) Transdermal Cream
- EDTA (calcium) Capsules
- EDTA (calcium) Injection
Several practitioners have requested we create a transdermal DMSA formulation for their patients. This request was due in large part to the often significant G.I. side effects that can occur when using oral DMSA therapy, and the difficulty in getting children to take DMSA by mouth
Transdermal DMSA has not been used in the past because DMSA exhibits a pungent odor, as well as poor stability in a topical formulation. Our expertise in the design of transdermal medications has allowed us to create a transdermal DMSA formulation that does not display these problems.
In addition, other transdermal chelation agents must be administered every other day. This can be very difficult for both the family and the child taking the chelating agent. Lee Silsby DMSA Transdermal Cream has an advantage over other chelating regimens in that it only needs to be dosed six times per month. Lee Silsby DMSA Transdermal Cream is administered three days in a row, followed by eleven days off. This fourteen-day cycle is then repeated.
Other forms of DMSA
- DMSA Suppositories
- DMSA Oral Liquid
- DMSA Capsules
Lee Silsby’s Stabilized Reduced Glutathione Transdermal Gel has been proven to maintain its stability.
The stability of a product refers to the ability of an active ingredient to retain its full potency when incorporated into a dosage form such as a capsule, liquid, cream, or gel. Many active ingredients decompose – either gradually or rapidly – when added to an improperly formulated dosage form.
Several years of research and development have led us to the creation of a formulation that we feel is the very best system for delivering reduced glutathione into the body. This was a particularly difficult task because of the poor stability of glutathione when added to a liquid, cream, or gel.
In order to insure that our glutathione formulation does, in fact, remain stable, we had it tested for stability by an independent laboratory. At the same time, another glutathione formulation commonly used by other compounding pharmacies was also tested for stability. The results of the testing showed that the glutathione in our transdermal gel formulation remained virtually 100% stable, while the glutathione in the standard formulation underwent rapid decomposition. In fact, as illustrated by the table above, the standard formulation lost 85% of its stability within three months.
Priding ourselves in our constant innovation in formulation development, we have recently made additional adjustments to our glutathione gel. These adjustments reflect our most current understanding about how best to achieve the highest skin absorption of topically applied medications. Our knowledge in this area has been developed through working with doctors and their patients on a clinical basis, as well as hundreds of hours of research into and development of transdermal dosage forms.
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