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Leucovorin for Cerebral Folate Deficiency in Autism

While there is no cure for autism, there are new therapies that hold promise for treating some of the more pervasive symptoms. 

Lee Silsby is excited to partner with leading specialists in the field— providing high-quality products for innovative studies that help make patients’ lives better.


One recent set of studies was conducted by Dr. Richard Frye, a child neurologist and leading autism researcher, after research suggested a link between cerebral folate deficiency and autism.


With 75% of autism patients displaying this deficiency, Dr. Frye and his team wanted to see if treatment with a folic acid compound known as Leucovorin would benefit these children.


The results were positive—dramatic, in fact.

Watch this interview with Dr. Frye to learn more about the folate/autism connection, how Leucovorin can help your patients, and the advantage of choosing Lee Silsby compounded medications.

As primary care physicians, you are a critical part of the care team for these patients—and with up-to-date treatments such as Leucovorin, you can help make a difference in the lives of these children and their families.


Read Dr. Frye's Study

Folinic acid improves verbal communication in children with autism and language impairment: a randomized double-blind placebo-controlled trial

Available As 

GF/CF/DF Capsules (various strengths)


GF/CF/DF/SF Oil Suspension (various strengths and flavors)

GF = gluten-free

CF = casein-free

DF= dye-free

SF = sugar-free

Insurance Coverage 

Many major insurance plans cover our compounded Leucovorin capsules and oral liquids.

Did You Know?

Manufactured Leucovorin drugs contain lactose, and many also contain titanium and other undesirable ingredients. Lee Silsby's formulations are free of these and other undesirable additives. 

Ready to prescribe Leucovorin now?

Download a Leucovorin prescription blank. Prescriptions may be faxed, phoned, or e-faxed to our pharmacy.  

Still have questions?

To speak to a Lee Silsby pharmacist about Leuvcovorin or other drug therapies for your patients, click here to schedule a consultation. 

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